Zachodniopomorski Uniwersytet Technologiczny w Szczecinie

Administracja Centralna Uczelni - Wymiana międzynarodowa (S2)

Sylabus przedmiotu In vitro and in vivo Methods in Toxicological Assessment of Xenobiotics:

Informacje podstawowe

Kierunek studiów Wymiana międzynarodowa
Forma studiów studia stacjonarne Poziom drugiego stopnia
Tytuł zawodowy absolwenta
Obszary studiów
Profil
Moduł
Przedmiot In vitro and in vivo Methods in Toxicological Assessment of Xenobiotics
Specjalność przedmiot wspólny
Jednostka prowadząca Katedra Biotechnologii Rozrodu Zwierząt i Higieny Środowiska
Nauczyciel odpowiedzialny Agnieszka Tomza-Marciniak <Agnieszka.Tomza-Marciniak@zut.edu.pl>
Inni nauczyciele Bogumiła Pilarczyk <Bogumila.Pilarczyk@zut.edu.pl>
ECTS (planowane) 4,0 ECTS (formy) 4,0
Forma zaliczenia zaliczenie Język angielski
Blok obieralny Grupa obieralna

Formy dydaktyczne

Forma dydaktycznaKODSemestrGodzinyECTSWagaZaliczenie
ćwiczenia audytoryjneA1 15 2,00,49zaliczenie
wykładyW1 15 2,00,51zaliczenie

Wymagania wstępne

KODWymaganie wstępne
W-1no requirements

Cele przedmiotu

KODCel modułu/przedmiotu
C-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
C-2To acquaint students with the mechanisms of action of toxic substances and their metabolism.
C-3To acquaint students with the computational methods in toxicity, exposure and risk assessment.

Treści programowe z podziałem na formy zajęć

KODTreść programowaGodziny
ćwiczenia audytoryjne
T-A-1Metabolism of xenobiotics.2
T-A-2The mechanisms of toxicity.2
T-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).3
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.3
T-A-5Toxicological evaluation of raw materials and cosmetic products.2
T-A-6Alternative methods in ecotoxicological studies.3
15
wykłady
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.2
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.2
T-W-3Acute toxicity - classic and alternative methods.4
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.3
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.2
T-W-6Chemical safety. The most important rules governing the issue of chemical safety. The classification and labeling of chemicals.2
15

Obciążenie pracą studenta - formy aktywności

KODForma aktywnościGodziny
ćwiczenia audytoryjne
A-A-1participation in lectures15
A-A-2studying indicated literature30
A-A-3learning to the test15
60
wykłady
A-W-1participation in lectures15
A-W-2studying indicated literature30
A-W-3learning to the test15
60

Metody nauczania / narzędzia dydaktyczne

KODMetoda nauczania / narzędzie dydaktyczne
M-1Delivery method, lecture/presentation.
M-2Discussion
M-3Explanation

Sposoby oceny

KODSposób oceny
S-1Ocena formująca: test
S-2Ocena formująca: assessment of student's activity and attitudes towards discussed issues.
S-3Ocena formująca: report

Zamierzone efekty uczenia się - wiedza

Zamierzone efekty uczenia sięOdniesienie do efektów kształcenia dla kierunku studiówOdniesienie do efektów zdefiniowanych dla obszaru kształceniaCel przedmiotuTreści programoweMetody nauczaniaSposób oceny
WM-WBiHZ_2-_null_W01
Student describes methods using in toxicity assessment of xenobiotics.
C-1T-A-6, T-W-5, T-W-1, T-W-2, T-W-3, T-W-4M-3, M-1, M-2S-1
WM-WBiHZ_2-_null_W02
Student desribes the metabolism of toxins and mechanisms of toxicity
C-1T-A-2, T-A-5, T-A-1M-3, M-1, M-2S-1

Zamierzone efekty uczenia się - umiejętności

Zamierzone efekty uczenia sięOdniesienie do efektów kształcenia dla kierunku studiówOdniesienie do efektów zdefiniowanych dla obszaru kształceniaCel przedmiotuTreści programoweMetody nauczaniaSposób oceny
WM-WBiHZ_2-_null_U01
Student uses the computational methods in toxicity, exposure and risk assessment.
C-3T-A-3, T-A-4M-3S-3

Zamierzone efekty uczenia się - inne kompetencje społeczne i personalne

Zamierzone efekty uczenia sięOdniesienie do efektów kształcenia dla kierunku studiówOdniesienie do efektów zdefiniowanych dla obszaru kształceniaCel przedmiotuTreści programoweMetody nauczaniaSposób oceny
WM-WBiHZ_2-_null_K01
Student understands the need to reduce the use of animals in toxicological studies.
C-1T-A-2, T-A-5, T-A-3, T-A-4, T-A-1, T-A-6, T-W-5, T-W-1, T-W-2, T-W-3, T-W-6, T-W-4M-3, M-1S-2

Kryterium oceny - wiedza

Efekt uczenia sięOcenaKryterium oceny
WM-WBiHZ_2-_null_W01
Student describes methods using in toxicity assessment of xenobiotics.
2,0
3,0The student lists and discribes the methods uses in toxicity assessment.
3,5
4,0
4,5
5,0
WM-WBiHZ_2-_null_W02
Student desribes the metabolism of toxins and mechanisms of toxicity
2,0
3,0Student describes phases of xenobiotic's metabolism and lists mechanisms of toxicity.
3,5
4,0
4,5
5,0

Kryterium oceny - umiejętności

Efekt uczenia sięOcenaKryterium oceny
WM-WBiHZ_2-_null_U01
Student uses the computational methods in toxicity, exposure and risk assessment.
2,0
3,0Student is able to calculate: the LD50 for a specific subtance (with using at least two methods), RfD, LOAL.
3,5
4,0
4,5
5,0

Kryterium oceny - inne kompetencje społeczne i personalne

Efekt uczenia sięOcenaKryterium oceny
WM-WBiHZ_2-_null_K01
Student understands the need to reduce the use of animals in toxicological studies.
2,0
3,0Student explains the reasons for reducing the number of animals in experimental studies.
3,5
4,0
4,5
5,0

Literatura podstawowa

  1. Michael Balls, Robert Combes and Andrew Worth, The History of Alternative Test Methods in Toxicology (1st edition), Elsevier, 2018

Treści programowe - ćwiczenia audytoryjne

KODTreść programowaGodziny
T-A-1Metabolism of xenobiotics.2
T-A-2The mechanisms of toxicity.2
T-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).3
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.3
T-A-5Toxicological evaluation of raw materials and cosmetic products.2
T-A-6Alternative methods in ecotoxicological studies.3
15

Treści programowe - wykłady

KODTreść programowaGodziny
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.2
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.2
T-W-3Acute toxicity - classic and alternative methods.4
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.3
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.2
T-W-6Chemical safety. The most important rules governing the issue of chemical safety. The classification and labeling of chemicals.2
15

Formy aktywności - ćwiczenia audytoryjne

KODForma aktywnościGodziny
A-A-1participation in lectures15
A-A-2studying indicated literature30
A-A-3learning to the test15
60
(*) 1 punkt ECTS, odpowiada około 30 godzinom aktywności studenta

Formy aktywności - wykłady

KODForma aktywnościGodziny
A-W-1participation in lectures15
A-W-2studying indicated literature30
A-W-3learning to the test15
60
(*) 1 punkt ECTS, odpowiada około 30 godzinom aktywności studenta
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięWM-WBiHZ_2-_null_W01Student describes methods using in toxicity assessment of xenobiotics.
Cel przedmiotuC-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
Treści programoweT-A-6Alternative methods in ecotoxicological studies.
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.
T-W-3Acute toxicity - classic and alternative methods.
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.
Metody nauczaniaM-3Explanation
M-1Delivery method, lecture/presentation.
M-2Discussion
Sposób ocenyS-1Ocena formująca: test
Kryteria ocenyOcenaKryterium oceny
2,0
3,0The student lists and discribes the methods uses in toxicity assessment.
3,5
4,0
4,5
5,0
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięWM-WBiHZ_2-_null_W02Student desribes the metabolism of toxins and mechanisms of toxicity
Cel przedmiotuC-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
Treści programoweT-A-2The mechanisms of toxicity.
T-A-5Toxicological evaluation of raw materials and cosmetic products.
T-A-1Metabolism of xenobiotics.
Metody nauczaniaM-3Explanation
M-1Delivery method, lecture/presentation.
M-2Discussion
Sposób ocenyS-1Ocena formująca: test
Kryteria ocenyOcenaKryterium oceny
2,0
3,0Student describes phases of xenobiotic's metabolism and lists mechanisms of toxicity.
3,5
4,0
4,5
5,0
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięWM-WBiHZ_2-_null_U01Student uses the computational methods in toxicity, exposure and risk assessment.
Cel przedmiotuC-3To acquaint students with the computational methods in toxicity, exposure and risk assessment.
Treści programoweT-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.
Metody nauczaniaM-3Explanation
Sposób ocenyS-3Ocena formująca: report
Kryteria ocenyOcenaKryterium oceny
2,0
3,0Student is able to calculate: the LD50 for a specific subtance (with using at least two methods), RfD, LOAL.
3,5
4,0
4,5
5,0
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięWM-WBiHZ_2-_null_K01Student understands the need to reduce the use of animals in toxicological studies.
Cel przedmiotuC-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
Treści programoweT-A-2The mechanisms of toxicity.
T-A-5Toxicological evaluation of raw materials and cosmetic products.
T-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.
T-A-1Metabolism of xenobiotics.
T-A-6Alternative methods in ecotoxicological studies.
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.
T-W-3Acute toxicity - classic and alternative methods.
T-W-6Chemical safety. The most important rules governing the issue of chemical safety. The classification and labeling of chemicals.
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.
Metody nauczaniaM-3Explanation
M-1Delivery method, lecture/presentation.
Sposób ocenyS-2Ocena formująca: assessment of student's activity and attitudes towards discussed issues.
Kryteria ocenyOcenaKryterium oceny
2,0
3,0Student explains the reasons for reducing the number of animals in experimental studies.
3,5
4,0
4,5
5,0