Zachodniopomorski Uniwersytet Technologiczny w Szczecinie

Wydział Biotechnologii i Hodowli Zwierząt - Biotechnologia (S2)

Sylabus przedmiotu In vitro and in vivo methods in toxicological assessment of xenobiotics:

Informacje podstawowe

Kierunek studiów Biotechnologia
Forma studiów studia stacjonarne Poziom drugiego stopnia
Tytuł zawodowy absolwenta magister inżynier
Obszary studiów charakterystyki PRK, kompetencje inżynierskie PRK
Profil ogólnoakademicki
Moduł
Przedmiot In vitro and in vivo methods in toxicological assessment of xenobiotics
Specjalność Biotechnology in animal production and environmental protection
Jednostka prowadząca Katedra Biotechnologii Rozrodu Zwierząt i Higieny Środowiska
Nauczyciel odpowiedzialny Agnieszka Tomza-Marciniak <Agnieszka.Tomza-Marciniak@zut.edu.pl>
Inni nauczyciele Bogumiła Pilarczyk <Bogumila.Pilarczyk@zut.edu.pl>
ECTS (planowane) 3,0 ECTS (formy) 3,0
Forma zaliczenia zaliczenie Język angielski
Blok obieralny 6 Grupa obieralna 2

Formy dydaktyczne

Forma dydaktycznaKODSemestrGodzinyECTSWagaZaliczenie
ćwiczenia audytoryjneA2 15 1,50,41zaliczenie
wykładyW2 15 1,50,59zaliczenie

Wymagania wstępne

KODWymaganie wstępne
W-1no requirements

Cele przedmiotu

KODCel modułu/przedmiotu
C-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
C-2To acquaint students with the mechanisms of action of toxic substances and their metabolism.
C-3To acquaint students with the computational methods in toxicity, exposure and risk assessment.

Treści programowe z podziałem na formy zajęć

KODTreść programowaGodziny
ćwiczenia audytoryjne
T-A-1Metabolism of xenobiotics.2
T-A-2The mechanisms of toxicity.2
T-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).3
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.3
T-A-5Toxicological evaluation of raw materials and cosmetic products.2
T-A-6Alternative methods in ecotoxicological studies.3
15
wykłady
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.2
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.2
T-W-3Acute toxicity - classic and alternative methods.4
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.3
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.2
T-W-6Chemical safety. The most important rules governing the issue of chemical safety. The classification and labeling of chemicals.2
15

Obciążenie pracą studenta - formy aktywności

KODForma aktywnościGodziny
ćwiczenia audytoryjne
A-A-1participation in lectures15
A-A-2studying indicated literature15
A-A-3preparation for test15
45
wykłady
A-W-1participation in lectures15
A-W-2studying indicated literature15
A-W-3preparation for test15
45

Metody nauczania / narzędzia dydaktyczne

KODMetoda nauczania / narzędzie dydaktyczne
M-1Delivery method, lecture/presentation.
M-2Discussion
M-3Explanation

Sposoby oceny

KODSposób oceny
S-1Ocena formująca: test
S-2Ocena formująca: assessment of student's activity and attitudes towards discussed issues.
S-3Ocena formująca: report

Zamierzone efekty uczenia się - wiedza

Zamierzone efekty uczenia sięOdniesienie do efektów kształcenia dla kierunku studiówOdniesienie do efektów zdefiniowanych dla obszaru kształceniaOdniesienie do efektów uczenia się prowadzących do uzyskania tytułu zawodowego inżynieraCel przedmiotuTreści programoweMetody nauczaniaSposób oceny
BT_2A_BTZ-A-O6.1_W01
Student describes methods using in toxicity assessment of xenobiotics.
BTap_2A_W01C-1T-A-6, T-W-1, T-W-2, T-W-3, T-W-5, T-W-4M-1, M-2, M-3S-1
BT_2A_BTZ-A-O6.1_W02
Student desribes the metabolism of toxins and mechanisms of toxicity
BTap_2A_W01C-1T-A-5, T-A-1, T-A-2M-1, M-2, M-3S-1

Zamierzone efekty uczenia się - umiejętności

Zamierzone efekty uczenia sięOdniesienie do efektów kształcenia dla kierunku studiówOdniesienie do efektów zdefiniowanych dla obszaru kształceniaOdniesienie do efektów uczenia się prowadzących do uzyskania tytułu zawodowego inżynieraCel przedmiotuTreści programoweMetody nauczaniaSposób oceny
BT_2A_BTZ-A-O6.1_U01
Student uses the computational methods in toxicity, exposure and risk assessment.
BTap_2A_U09C-3T-A-3, T-A-4M-3S-3

Zamierzone efekty uczenia się - inne kompetencje społeczne i personalne

Zamierzone efekty uczenia sięOdniesienie do efektów kształcenia dla kierunku studiówOdniesienie do efektów zdefiniowanych dla obszaru kształceniaOdniesienie do efektów uczenia się prowadzących do uzyskania tytułu zawodowego inżynieraCel przedmiotuTreści programoweMetody nauczaniaSposób oceny
BT_2A_BTZ-A-O6.1_K01
Student understands the need to reduce the use of animals in toxicological studies.
BTap_2A_K06C-1T-A-5, T-A-1, T-A-2, T-A-3, T-A-4, T-A-6, T-W-6, T-W-1, T-W-2, T-W-3, T-W-5, T-W-4M-1, M-3S-2

Kryterium oceny - wiedza

Efekt uczenia sięOcenaKryterium oceny
BT_2A_BTZ-A-O6.1_W01
Student describes methods using in toxicity assessment of xenobiotics.
2,0
3,0The student lists and discribes the methods uses in toxicity assessment.
3,5
4,0
4,5
5,0
BT_2A_BTZ-A-O6.1_W02
Student desribes the metabolism of toxins and mechanisms of toxicity
2,0
3,0Student describes phases of xenobiotic's metabolism and lists mechanisms of toxicity.
3,5
4,0
4,5
5,0

Kryterium oceny - umiejętności

Efekt uczenia sięOcenaKryterium oceny
BT_2A_BTZ-A-O6.1_U01
Student uses the computational methods in toxicity, exposure and risk assessment.
2,0
3,0Student is able to calculate: the LD50 for a specific subtance (with using at least two methods), RfD, LOAL.
3,5
4,0
4,5
5,0

Kryterium oceny - inne kompetencje społeczne i personalne

Efekt uczenia sięOcenaKryterium oceny
BT_2A_BTZ-A-O6.1_K01
Student understands the need to reduce the use of animals in toxicological studies.
2,0
3,0Student explains the reasons for reducing the number of animals in experimental studies.
3,5
4,0
4,5
5,0

Literatura podstawowa

  1. Seńczuk (ed.), Toksykologia współczesna, PWN, Warszawa, 2006
  2. https://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788, 2011

Treści programowe - ćwiczenia audytoryjne

KODTreść programowaGodziny
T-A-1Metabolism of xenobiotics.2
T-A-2The mechanisms of toxicity.2
T-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).3
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.3
T-A-5Toxicological evaluation of raw materials and cosmetic products.2
T-A-6Alternative methods in ecotoxicological studies.3
15

Treści programowe - wykłady

KODTreść programowaGodziny
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.2
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.2
T-W-3Acute toxicity - classic and alternative methods.4
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.3
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.2
T-W-6Chemical safety. The most important rules governing the issue of chemical safety. The classification and labeling of chemicals.2
15

Formy aktywności - ćwiczenia audytoryjne

KODForma aktywnościGodziny
A-A-1participation in lectures15
A-A-2studying indicated literature15
A-A-3preparation for test15
45
(*) 1 punkt ECTS, odpowiada około 30 godzinom aktywności studenta

Formy aktywności - wykłady

KODForma aktywnościGodziny
A-W-1participation in lectures15
A-W-2studying indicated literature15
A-W-3preparation for test15
45
(*) 1 punkt ECTS, odpowiada około 30 godzinom aktywności studenta
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięBT_2A_BTZ-A-O6.1_W01Student describes methods using in toxicity assessment of xenobiotics.
Odniesienie do efektów kształcenia dla kierunku studiówBTap_2A_W01has an extended knowledge in the field of biology, chemistry, mathematics, physics and related sciences adapted to the biotechnology field
Cel przedmiotuC-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
Treści programoweT-A-6Alternative methods in ecotoxicological studies.
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.
T-W-3Acute toxicity - classic and alternative methods.
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.
Metody nauczaniaM-1Delivery method, lecture/presentation.
M-2Discussion
M-3Explanation
Sposób ocenyS-1Ocena formująca: test
Kryteria ocenyOcenaKryterium oceny
2,0
3,0The student lists and discribes the methods uses in toxicity assessment.
3,5
4,0
4,5
5,0
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięBT_2A_BTZ-A-O6.1_W02Student desribes the metabolism of toxins and mechanisms of toxicity
Odniesienie do efektów kształcenia dla kierunku studiówBTap_2A_W01has an extended knowledge in the field of biology, chemistry, mathematics, physics and related sciences adapted to the biotechnology field
Cel przedmiotuC-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
Treści programoweT-A-5Toxicological evaluation of raw materials and cosmetic products.
T-A-1Metabolism of xenobiotics.
T-A-2The mechanisms of toxicity.
Metody nauczaniaM-1Delivery method, lecture/presentation.
M-2Discussion
M-3Explanation
Sposób ocenyS-1Ocena formująca: test
Kryteria ocenyOcenaKryterium oceny
2,0
3,0Student describes phases of xenobiotic's metabolism and lists mechanisms of toxicity.
3,5
4,0
4,5
5,0
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięBT_2A_BTZ-A-O6.1_U01Student uses the computational methods in toxicity, exposure and risk assessment.
Odniesienie do efektów kształcenia dla kierunku studiówBTap_2A_U09uses the learned methods in research work; develops the literature in accordance with the research profile; analyzes scientific reports and other source materials in the context of own research project; is able to prepare a project of his/her own scientific research and prepare a scientific study himself/herself
Cel przedmiotuC-3To acquaint students with the computational methods in toxicity, exposure and risk assessment.
Treści programoweT-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.
Metody nauczaniaM-3Explanation
Sposób ocenyS-3Ocena formująca: report
Kryteria ocenyOcenaKryterium oceny
2,0
3,0Student is able to calculate: the LD50 for a specific subtance (with using at least two methods), RfD, LOAL.
3,5
4,0
4,5
5,0
PoleKODZnaczenie kodu
Zamierzone efekty uczenia sięBT_2A_BTZ-A-O6.1_K01Student understands the need to reduce the use of animals in toxicological studies.
Odniesienie do efektów kształcenia dla kierunku studiówBTap_2A_K06demonstrates responsibility for the decisions made and their consequences; presents a substantive and critical attitude
Cel przedmiotuC-1To acquaint students with the in vivo and in vitro methods used in assessing the toxicity of xenobiotics.
Treści programoweT-A-5Toxicological evaluation of raw materials and cosmetic products.
T-A-1Metabolism of xenobiotics.
T-A-2The mechanisms of toxicity.
T-A-3Methods for determining the median lethal dose/concentration (LD50 i LC50).
T-A-4Calculation methods in the toxicity assessment. Exposure and risk assessment. Determination of NOAEL, LOAEL, LoAL and RfD.
T-A-6Alternative methods in ecotoxicological studies.
T-W-6Chemical safety. The most important rules governing the issue of chemical safety. The classification and labeling of chemicals.
T-W-1The use of animals in toxicometric research. The main organizations promoting alternative methods in the world. Database of in vitro techniques used in toxicology.
T-W-2Use of in vivo tests in evaluation of the toxicity of chemicals. Types and directions of toxicological research.
T-W-3Acute toxicity - classic and alternative methods.
T-W-5Evaluation of toxicity of a compound based on the relationship between the chemical structure and biological activity (structure-activity relationship). Factors affecting the toxicity. Genetic factors increasing the sensitivity to chemical compounds.
T-W-4Repeated dose toxicity. The methods used in assessing the genotoxicity, carcinogenicity, neurotoxicity, effects on reproduction, fertility and offspring.
Metody nauczaniaM-1Delivery method, lecture/presentation.
M-3Explanation
Sposób ocenyS-2Ocena formująca: assessment of student's activity and attitudes towards discussed issues.
Kryteria ocenyOcenaKryterium oceny
2,0
3,0Student explains the reasons for reducing the number of animals in experimental studies.
3,5
4,0
4,5
5,0